Research Interest: Neuropathology, molecular pathology of tumors, general  and pediatric pathology

Current position:
2011- present : Associate Professor of Medical Genetics (Area A1/06- SSD MED03), University of Chieti-Pescara  Italy On April  2017, VG obtained the National Scientific Qualification as Full Professor  in Medical Genetics  (SSD MED/03)

Previous positions:
2005-2011:  University Researcher (Medical Genetics - MED 03) University of Chieti-Pescara ( Italy)
2002-2005: Post-Phd Fellowship supported by University of Chieti.
1995- Fellowship supported by European Structural Funds. Research area:  Biological and Medical Science carried out at the  Centro di Genetica Evoluzionistica- CNR Rome

Research Interest: During the course of her scientific activity, VG  worked in the field of molecular genetics, using the most recent techniques for the study of gene mutations causing pathologies such as male infertility, short stature (linked to mutations of the SHOX gene), familiar breast cancer (due to mutations of the BRCA1 and BRCA2 genes), Van Der Woude syndrome (IRF6 gene), and several neuromuscular diseases (Duchenne Muscular Dystrohpy, distal SMA, and others).
 She is head of a research team, working in the CAST research Centre of Chieti University specialized in molecular genetics.
 During these years VG primary interest was the study of the molecular basis of human reproduction and  she is currently investigating molecular mechanisms involved in oocyte competence and male infertility.
 These studies have been carried out by VG using a variety of molecular genetics technique like PCR, Southern Blot, DNA sequencing, as well as Multiple Ligation-Dependent Probe Amplification (MLPA). In the last few years, she has employed Real Time PCR, microarray , HRM, pyrosequencing and NGS technologies to investigate the modulation of gene expression profile in  different  models and SNPs (oocyte mitochondrial DNA, sperm, cumulus cells, oocyte, Transgenic Mouse Models of AD, stem cells).

URL: https://www.unich.it/ugov/person/1475

Number of publications: 10

Research Interest: Forensic Odontology; Forensic Anthropology; Dental malpratice litigation

Research Interest: genetic studies, molecular biology, rheumatology, autoimmune diseases, polymorphisms and mutation, RNA and protein levels, T cells, transcriptional factors, cytokines, angiogenesis, signaling pathways in immune responses, inflammation

Research Interest: Ectodermal Dysplasia, hypodontia, rare diseases, genetic diseases, hyperdontia, oral manifestations, Cleidocranial Dysplasia, Amelogenesis Imperfecta, Dentinogenesis Imperfecta, X linked reticulated pigmentary disorder, Turner Syndrome, Williams-Beuren syndrome, Alagille Syndrome, Neurofibromatosis, Cornelia de Lange Syndrome, Allgrove Syndrome, delopmental biology

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Mechanism(s) of neurotransmitter and hormone synthesis, secretion and action, and the associated cellular regulatory pathways and their modulation by pharmacological agents. I am also interested in the effects of pharmacological and dietary modulation (medical foods, herbs, behavioural techniques etc) of metabolic, cellular, organ and systemic levels. I am especially interested in the age-related diseases, such as cancer, neurodegeneration. Expertise in the prevention of CNS/PNS damage in conditions related to metabolic syndrome (diabetes), stroke, ischemia, hypoxia and diseases like Alzheimer’s and Parkinson’s

Research Interest: Pediatrics, endocrinology, short stature, puberty, obesity, genetics

Research Interest: Molecular biology and pathogenesis of herpesviruses, molecular mechanisms of establisment of latency and virus reactivation from latency in vitro and in vivo, molecular genetics of attenuattion and regulation of gene expression

Graduated in Biological Sciences at the University of Catania, CNR scholarship holder, specialized in "Experimental Medicine", technical officer in charge of the Cellular Physiology laboratory of the Department of Physiological Sciences, Researcher and Assistant Professor for the disciplinary sector BIO/09 Physiology, she is currently Associate Professor of Physiology at the Department of Biomedical and Biotechnological Sciences of the University of Catania. She holds the national scientific qualification as Full Professor for the scientific disciplinary sector BIO/09 Physiology.

She has carried out teaching activities for the degree courses in Natural Sciences (five-year), Biological Sciences (five-year), Ecological Sciences and Environmental Education (level I) and Environmental Sciences (level II). She currently teaches General and Environmental Physiology (9 C.F.U.) for the Degree Course in Environmental and Natural Sciences (1st level), Ecophysiological Adaptations to the Environment for the Degree Course in Environmental Biology, Physiology for the Degree Courses in Nursing, Radiology and Radiotherapy Technicians, and Environmental Safety Technicians, and Biophysics Physiology I Channel A and Channel C (8 C.F.U.) for the Degree Course in Medicine and Surgery (five-year).

She has held lessons for the second level University Masters "Monitoring and assessment of environmental, mutagenic, carcinogenic and teratogenic risk" and "Monitoring of ionizing and non-ionizing radiation and environmental risk", at the theoretical-practical training and professional development course organized in Catania by the National Order of Biologists, at the specialized training course "New figures of advanced technology specialists for the identification and analysis of biomarkers in the oncology sector" entrusted by the Company Medical Sciences s.r.l. within the Industrial Research and Training Project PON01_02418 and for the National Research Council (CNR) - Institute of Neurological Sciences UOS of Catania within the training project connected to the Project "DNA on Disk: Diagnostic platform and kits for human health in the oncology, neurological and infectious diseases and poverty-related diseases" - CTN01_00177_817708, financed by the resources of the program National Operational "Research & Competitiveness (PON "R&C") PON01_0248.

Research Interest: Environmental Physiology,Cell cultures; Cell models; Cell physiology; Signal transduction; Gene expression; Proteomics; Mesenchymal stem cell biology and differentiation ; Krabbe disease, e

Research Interest: Gene expression, gene therapy, cell biology, neurodegenerative disease, male and female infertility.

Research Interest: Cardiovascular disease epidemiology, hypertensive heart disease, cardiovascular imaging and genetic epidemiology of cardiovascular diseases.

Research Interest: Head and Neck Cancer Objetivos:Epidemiology and Head and Neck pathology. Biomarkers of prognostic in Head and Neck tumors

Research Interest: Epidemiology and  pathophysiology of ischemic stroke Inflammatory  activation of the acute phase of acute ischemic stroke in relation of  subtypes of ischemic stroke,CD4+CD28- T cells in acute ischemic stroke  killer cell immunoglobulin-like receptors (KIR) receptors in acute clinical subtypes of acute ischemic stroke Treatment with  high-dose furosemide and small-volume hypertonic saline therapy in refractory heart failure Treatment with  high-dose furosemide and small-volume hypertonic saline therapy in refractory ascites diabetic foot as a cardiovascular risk marker Anderson-Fabry disease