Current position:
2011- present : Associate Professor of Medical Genetics (Area A1/06- SSD MED03), University of Chieti-Pescara  Italy On April  2017, VG obtained the National Scientific Qualification as Full Professor  in Medical Genetics  (SSD MED/03)

Previous positions:
2005-2011:  University Researcher (Medical Genetics - MED 03) University of Chieti-Pescara ( Italy)
2002-2005: Post-Phd Fellowship supported by University of Chieti.
1995- Fellowship supported by European Structural Funds. Research area:  Biological and Medical Science carried out at the  Centro di Genetica Evoluzionistica- CNR Rome

Research Interest: During the course of her scientific activity, VG  worked in the field of molecular genetics, using the most recent techniques for the study of gene mutations causing pathologies such as male infertility, short stature (linked to mutations of the SHOX gene), familiar breast cancer (due to mutations of the BRCA1 and BRCA2 genes), Van Der Woude syndrome (IRF6 gene), and several neuromuscular diseases (Duchenne Muscular Dystrohpy, distal SMA, and others).
 She is head of a research team, working in the CAST research Centre of Chieti University specialized in molecular genetics.
 During these years VG primary interest was the study of the molecular basis of human reproduction and  she is currently investigating molecular mechanisms involved in oocyte competence and male infertility.
 These studies have been carried out by VG using a variety of molecular genetics technique like PCR, Southern Blot, DNA sequencing, as well as Multiple Ligation-Dependent Probe Amplification (MLPA). In the last few years, she has employed Real Time PCR, microarray , HRM, pyrosequencing and NGS technologies to investigate the modulation of gene expression profile in  different  models and SNPs (oocyte mitochondrial DNA, sperm, cumulus cells, oocyte, Transgenic Mouse Models of AD, stem cells).

URL: https://www.unich.it/ugov/person/1475

Number of publications: 10

Research Interest: Identification of the Gene Responsible for Hereditary Deafness and Onycodystrophy Syndrome and Functional Study on the Gene

Research Interest: Molecular biology and pathogenesis of herpesviruses, molecular mechanisms of establisment of latency and virus reactivation from latency in vitro and in vivo, molecular genetics of attenuattion and regulation of gene expression

Research Interest: Head and Neck Cancer Objetivos:Epidemiology and Head and Neck pathology. Biomarkers of prognostic in Head and Neck tumors

Research Interest: Diabetes and its Complications, Osteoporosis, Cardiovascular Disease, Neuropathy; Mathematical Modelling for Human Complex Disease; Policy and Clinical Decision Analysis in Medical Science; Stochastic Process Analysis and Bayesian Analysis for Clinical Medicine; Mathematical Methodology Development for Clinical Science; Gene Mapping and Identification of Human Complex Disease; Data Analysis for Results of Experiment

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Analysis of genomic data including next-generation sequencing, microarrays data etc.; development of algorithms for discovery of predictive biomarkers for cancer such as gene mutation signatures and gene expression signatures; systems and computational biology for elucidating the nature of oncogenesis; inference of molecular interaction networks relevant to specific disease; inference of cancer genomic evolution based on gene mutation information; identification of synthetic lethal genes for cancer therapy.

Research Interest: Genetics

Research Interest: Inflammatory responses, bone regeneration, bone metabolism, osteoclast, osteoblast, mesenchymal stem cell, signal transduction, cancer-induced bone diseases.