Dr Toma is senior research officer at Neuroscience Research Australia (NeuRA) and holds a conjoint lecturer position at School of Medical science (University of New South Wales). He obtained his PhD in human genetics at the University of Bologna (Italy) and carried out research projects in the genetics of neurodevelopmental disorders at the Wellcome Trust Centre for Human Genetics (University of Oxford, UK) and in the genetics of psychiatric and Mendelian diseases at the University of Barcelona (Spain).  Dr Toma has extensive experience in association studies, linkage studies, copy number variant (CNV) analyses and whole exome/genome sequencing. He has identified novel candidate genes for autism spectrum disorder and bipolar disorder, and suggested new genetic mechanisms.

Research Interest: Genetics of psychiatric diseases

Number of Publications: 31

Research Interest: Cancer biology, Cancer biomarkers, Cancer cells, Cancer research, Copy number variants, Epigenetics, Gene expression, Genomics, Gene regulation, Human genetics, Microarray analysis, microRNA, Molecular Oncology, Transcriptomics

Graduated in Biological Sciences at the University of Catania, CNR scholarship holder, specialized in "Experimental Medicine", technical officer in charge of the Cellular Physiology laboratory of the Department of Physiological Sciences, Researcher and Assistant Professor for the disciplinary sector BIO/09 Physiology, she is currently Associate Professor of Physiology at the Department of Biomedical and Biotechnological Sciences of the University of Catania. She holds the national scientific qualification as Full Professor for the scientific disciplinary sector BIO/09 Physiology.

She has carried out teaching activities for the degree courses in Natural Sciences (five-year), Biological Sciences (five-year), Ecological Sciences and Environmental Education (level I) and Environmental Sciences (level II). She currently teaches General and Environmental Physiology (9 C.F.U.) for the Degree Course in Environmental and Natural Sciences (1st level), Ecophysiological Adaptations to the Environment for the Degree Course in Environmental Biology, Physiology for the Degree Courses in Nursing, Radiology and Radiotherapy Technicians, and Environmental Safety Technicians, and Biophysics Physiology I Channel A and Channel C (8 C.F.U.) for the Degree Course in Medicine and Surgery (five-year).

She has held lessons for the second level University Masters "Monitoring and assessment of environmental, mutagenic, carcinogenic and teratogenic risk" and "Monitoring of ionizing and non-ionizing radiation and environmental risk", at the theoretical-practical training and professional development course organized in Catania by the National Order of Biologists, at the specialized training course "New figures of advanced technology specialists for the identification and analysis of biomarkers in the oncology sector" entrusted by the Company Medical Sciences s.r.l. within the Industrial Research and Training Project PON01_02418 and for the National Research Council (CNR) - Institute of Neurological Sciences UOS of Catania within the training project connected to the Project "DNA on Disk: Diagnostic platform and kits for human health in the oncology, neurological and infectious diseases and poverty-related diseases" - CTN01_00177_817708, financed by the resources of the program National Operational "Research & Competitiveness (PON "R&C") PON01_0248.

Research Interest: Environmental Physiology,Cell cultures; Cell models; Cell physiology; Signal transduction; Gene expression; Proteomics; Mesenchymal stem cell biology and differentiation ; Krabbe disease, e

Research Interest: Mechanisms of cell signaling pathway of cell death Cancer Biology Mechanisms of anti-cancer effect of cancer chemopreventive agents

Research Interest: Endocrinology, Molecular Cell Biology, Medical Genetic, Biochemistry, Genomic, Bioinformatics, Drug Discovery

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Diabetes and its Complications, Osteoporosis, Cardiovascular Disease, Neuropathy; Mathematical Modelling for Human Complex Disease; Policy and Clinical Decision Analysis in Medical Science; Stochastic Process Analysis and Bayesian Analysis for Clinical Medicine; Mathematical Methodology Development for Clinical Science; Gene Mapping and Identification of Human Complex Disease; Data Analysis for Results of Experiment

Research Interest: Genomics Application in Auditory Disease; Novel Deafness Gene and Mutations Identification; Next Generation Sequencing

Research Interest: Experienced in Molecular Biologic, Cellular Biologic, and Immunologic Techniques; Expert at Flow Cytometry, ELISA, Real-Time PCR, and Luciferase Reporter Gene Assay.

Current Research is focused on the Diagnostic and Therapeutic Role of B-Cell-Activating Factor (BAFF) in Autoimmune Disorders

Research Interest: Neuropathology, molecular pathology of tumors, general  and pediatric pathology

Research Interest: Genetics

Research Interest: Biological Sciences, Genetics, Subarea: Molecular Genetics of Microorganisms and Major Agrarian Sciences, Agronomy, Plant, Specialty: Vegetable Improvement  Major, Agrarian Sciences, Agronomy, Subarea: Plant, Specialty: Management and Cultural Abuse