Research Interest: Drug delivery, Tissue Engineering, Cancer therapy

Research Interest: Genetic disease involving craniofacial complex and teeth

Research Interest: "Molecular Genetics Study on Inherited Hematologic Diseases Clinical Pharmacogenetics Study based on Next Generation Sequencing Methylation Study on Cancer Diagnostic Approaches based on Bio-interfacial Kinetics and Thermodynamics Study Microarray"

Research Interest: (1) Developing new NGS data analysis methods and tools; (2) Clinic result prediction with NGS data; (3) Integration of omics data from different platforms

Research Interest: Genetic Epidemiology, Quantitative Genetics, Human Health Across the Life Course, Dental and Oral Health, and Translational and Stratified Medicine

Research Interest: Development and testing of improved expression cassettes for expressing transgenes from helper-dependent adenovirus (HDAd) in endothelial cells and development and testing of IL-10 and ApoAI-expressing vectors for athero-protective gene therapy.

Research Interest: Urogynecology, sexual dysfunction, incontinence

Research Interest: Plant Genetics, Biotechnology, Physiology and Bioactive Accumulation by Plants

Research Interest: Cancer genomics, Human genetics, Molecular genetics

Research Interest: "Identification of New Biomarker for Genetic or Epigenetic target genes in Cancer - Cancer Cell Metabolism and Target Discovery in Resistance Cancer Cells "

Research Interest: Animal Molecular Genetics and Biotechnology

Research Interest: Developmental delay in language and cognition, Williams syndrome, Down syndrome, language impairment

Research Interest: Probiotics, shiga toxin producing Eschercihia coli, reservoirs, food borne pathogens 

Research Interest: Current research is focused on the diagnostic and therapeutic role of B-cell-activating factor (BAFF) in autoimmune disorders

Research Interest: Microbial pharmaceuticals

Research Interest: Inherited hearing loss, Mechanisms of hearing loss, Genetic counseling

Research Interest: Currently my researches focus on the liver fat metabolism and the molecular mechanism of metastasis and screening for biomarkers in gastric cancer.

Research Interest: Molecular diagnostics and bioinformatics of Medical Parasitology

Work Experience:

2021.10-    Lecturer, Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, Department of Physiology, Shanxi Medical University

Educational Experience:

PhD in Agriculture Science, Southwest University, 2012-2020

BSc in Agriculture Science, Shandong Agricultural University, 2008-2012

Research Interest: Genome editing, Genetics, Angiocarpy

List of Publications:

1. Jiasong Chang#, Ruolin Wang#, Kai Yu,. et al. Genome-wide CRISPR screening reveals genes essential for cell viability and resistance to abiotic and biotic stresses in Bombyx mori. 2020, Genome Research, 30(5), 757-767.
2. Jiasong Chang, Xiaoxu Chen, Tong Zhang,. et al. The novel insight into the outcomes of CRISPR/Cas9 editing intraand inter-species. 2020, INT J BIOL MACROMOL. 2020 Nov 15;163:711-717.
3. Jiasong Chang , Xiaoxu Chen , Ruolin Wang ,. et al. High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. 2020, Molecules. 25 (2) :353.
4. Sanyuan Ma#, Jiasong Chang#, Xiaogang Wang,. et al. CRISPR/Cas9 mediated heritable knock out of BmKu70 in silkworm, Bombyx mori. 2014, Scientific reports. 4:4489. Co-first author.
5. Yue Liu, Jiasong Chang, Chengfei Yang, Tong Zhang, Xiaoxu Chen, Run Shi, Yan Liang, Qingyou Xia, Sanyuan Ma, Genome-wide CRISPR-Cas9 screening in Bombyx mori reveals the toxicological mechanisms of environmental pollutants, fluoride and cadmium. 2021, J Hazard Mater, May 15;410:124666.
6. Yuanyuan Liu#, Sanyuan Ma#, Jiasong Chang, Tong Zhang, Xiaogang Wang, Run Shi, Jianduo Zhang, Wei Lu, Yue Liu, Qingyou Xia*. Tissue-specific Genome Editing of laminA/C in the Posterior Silk Glands of Bombyx Mori. 2017, J Genet Genomics, 44 (9), 451-459.
7. Yue Liu, Sanyuan Ma, Jiasong Chang, Tong Zhang, Xiaoxu Chen, Yan Liang, Qingyou Xia*. Programmable Targeted Epigenetic Editing Using CRISPR System in Bombyx Mori. 2019, Insect Biochem Mol Biol, 110, 105-111.
8. Xiaogang Wang, Sanyuan Ma, Jiasong Chang, Run Shi, Ruolin Wang, Ping Zhao, Qingyou Xia*. Programmable Activation of Bombyx Gene Expression Using CRISPR/dCas9 Fusion Systems. 2019, Insect Sci, 26 (6), 983-990.
9. Sanyuan Ma#, Yue Liu#, Yuanyuan Liu, Jiasong Chang, Tong Zhang, Xiaogang Wang, Run Shi, Wei Lu, Xiaojuan Xia, Ping Zhao, Qingyou Xia*. An Integrated CRISPR Bombyx Mori Genome Editing System With Improved Efficiency and Expanded Target Sites. 2017, Insect Biochem Mol Biol. 83, 13-20.
10. Sanyuan Ma#, Run Shi#, Xiaogang Wang, Yuanyuan Liu, Jiasong Chang, Jie Gao, Wei Lu, Jianduo Zhang, Ping Zhao, Qingyou Xia*. Genome editing of BmFib-H gene provides an empty Bombyx mori silk gland for a highly efficient bioreactor. 2014, Scientific reports. 4:6867.
11. Yufeng Li#, Sanyuan Ma#, Le Sun, Tong Zhang, Jiasong Chang, Wei Lu, Xiaoxu Chen, Yue Liu, Xiaogang Wang, Run Shi, Ping Zhao*, and Qingyou Xia*. Programmable Single and Multiplex Base-Editing in Bombyx mori Using RNA-Guided Cytidine Deaminases. 2018, G3 (Bethesda), 8 (5), 1701-1709.
12. Yuanyuan Liu#, Sanyuan Ma#, Xiaogang Wang, Jiasong Chang, Jie Gao, Run Shi, Jianduo Zhang, Wei Lu, Yue Liu, Ping Zhao and Qingyou Xia*. Highly efficient multiplex targeted mutagenesis and genomic structure variation in Bombyx mori using CRISPR/Cas9. 2014, Insect Biochem Mol Biol. 49:35-42.
13. Run Shi, Sanyuan Ma, Ting He, Jian Peng, Tong Zhang, Xiaoxu Chen, Xiaogang Wang, Jiasong Chang, Qingyou Xia and Ping Zhao*. Deep Insight into the Transcriptome of the Single Silk Gland of Bombyx mori. (2019. Int J Mol Sci, 20 (10).
14. Sanyuan Ma, Xiaogang Wang, Yuanyuan Liu, Jie Gao, Shengling Zhang, Run Shi, Jiasong Chang, Ping Zhao and Qingyou Xia*. Multiplex genomic structure variation mediated by TALEN and ssODN. 2014, BMC Genomics. 15(1):41.
15. Sanyuan Ma#, Xiaojuan Xia#, Yufeng Li, Le Sun, Yue Liu, Yuanyuan Liu, Xiaogang Wang, Run Shi, Jiasong Chang, Ping Zhao and Qingyou Xia*. Increasing the Yield of Middle Silk Gland Expression System Through Transgenic Knock-Down of Endogenous sericin-1. 2017, Mol Genet Genomics, 292 (4), 823-831.