Research Interest: Molecular Ecology: Biological Resources Indicator species application of ecological risk assessment Microbial Indicators Molecular genetics of arsenic resistance system bacteria

Research Interest: Gene expression, gene therapy, cell biology, neurodegenerative disease, male and female infertility.

Research Interest: Clinical research is in caveolin-1 (and related candidate gene) single nucleotide polymorphism in kidney disease, transplantation, patient related morbidity as well as basic science research of caveolin-1, its knockout, pericytes in models of renal fibrosis and methods to reintroduce caveolin-1 using viromimetic vectors. Other research interests include cytomegalovirus risk, allograft outcome prediction, medications effects in transplantation.

Research Interest: Experienced in Molecular Biologic, Cellular Biologic, and Immunologic Techniques; Expert at Flow Cytometry, ELISA, Real-Time PCR, and Luciferase Reporter Gene Assay.

Current Research is focused on the Diagnostic and Therapeutic Role of B-Cell-Activating Factor (BAFF) in Autoimmune Disorders

Research Interest: Epigenomics and pharmacogenomics in anti-cancer chemotherapy (Epi)Genetics and (epi)genomics for cancers and complex diseases

Research Interest: Epidemiology and  pathophysiology of ischemic stroke Inflammatory  activation of the acute phase of acute ischemic stroke in relation of  subtypes of ischemic stroke,CD4+CD28- T cells in acute ischemic stroke  killer cell immunoglobulin-like receptors (KIR) receptors in acute clinical subtypes of acute ischemic stroke Treatment with  high-dose furosemide and small-volume hypertonic saline therapy in refractory heart failure Treatment with  high-dose furosemide and small-volume hypertonic saline therapy in refractory ascites diabetic foot as a cardiovascular risk marker Anderson-Fabry disease

Research Interest: Genomics Application in Auditory Disease; Novel Deafness Gene and Mutations Identification; Next Generation Sequencing

Research Interest: Protein expression, purification, crystallization and structure determination Sign a transaction and transcription regulation Chemistry, drug design, origin of life and quantum chemistry

Research Interest: Epigenetics in glioma, especially methylation patterns, Stem cell research in glioma

Research Interest: Head and Neck Cancer Objetivos:Epidemiology and Head and Neck pathology. Biomarkers of prognostic in Head and Neck tumors

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Water composition and nutrition Genetics in Inborn Error Metabolism Nutrition in Pediatrics

Research Interest: The immunology and immunogenetic of tuberculosis and sarcoidosis with particular interests in the role of HLA, NRAMP1 and participation of M. tuberculosis heat shock proteins in the pathogenesis of sarcoidosis; Mycobacterial heat shock proteins and their role in sarcoidosis and tuberculosis.