Research Interest: Systems biology research for brain arteriovenous, malformation

Research Interest: Head and Neck Cancer Objetivos:Epidemiology and Head and Neck pathology. Biomarkers of prognostic in Head and Neck tumors

Research Interest: Biological Sciences, Genetics, Subarea: Molecular Genetics of Microorganisms and Major Agrarian Sciences, Agronomy, Plant, Specialty: Vegetable Improvement  Major, Agrarian Sciences, Agronomy, Subarea: Plant, Specialty: Management and Cultural Abuse

Research Interest: Identification of the Gene Responsible for Hereditary Deafness and Onycodystrophy Syndrome and Functional Study on the Gene

Research Interest: Mechanism(s) of neurotransmitter and hormone synthesis, secretion and action, and the associated cellular regulatory pathways and their modulation by pharmacological agents. I am also interested in the effects of pharmacological and dietary modulation (medical foods, herbs, behavioural techniques etc) of metabolic, cellular, organ and systemic levels. I am especially interested in the age-related diseases, such as cancer, neurodegeneration. Expertise in the prevention of CNS/PNS damage in conditions related to metabolic syndrome (diabetes), stroke, ischemia, hypoxia and diseases like Alzheimer’s and Parkinson’s

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Biomarkers for the early detection and targeted therapeutics for triple negative breast cancer, oxidative stress and its role in linking cancer and diabetes, development of protein based biologics, clathrin coated pit-mediated endocytosis and its downstream signaling, drug delivery, syngeneic and xenografts mice model.

Research Interest: Water composition and nutrition Genetics in Inborn Error Metabolism Nutrition in Pediatrics

Research Interest: Analysis of genomic data including next-generation sequencing, microarrays data etc.; development of algorithms for discovery of predictive biomarkers for cancer such as gene mutation signatures and gene expression signatures; systems and computational biology for elucidating the nature of oncogenesis; inference of molecular interaction networks relevant to specific disease; inference of cancer genomic evolution based on gene mutation information; identification of synthetic lethal genes for cancer therapy.

Research Interest: Mechanisms of cell signaling pathway of cell death Cancer Biology Mechanisms of anti-cancer effect of cancer chemopreventive agents

Research Interest: IRS1 IRS2,miR-200a,insulin/IGF signaling,paraganglioma,APC gene

Graduated in Biological Sciences at the University of Catania, CNR scholarship holder, specialized in "Experimental Medicine", technical officer in charge of the Cellular Physiology laboratory of the Department of Physiological Sciences, Researcher and Assistant Professor for the disciplinary sector BIO/09 Physiology, she is currently Associate Professor of Physiology at the Department of Biomedical and Biotechnological Sciences of the University of Catania. She holds the national scientific qualification as Full Professor for the scientific disciplinary sector BIO/09 Physiology.

She has carried out teaching activities for the degree courses in Natural Sciences (five-year), Biological Sciences (five-year), Ecological Sciences and Environmental Education (level I) and Environmental Sciences (level II). She currently teaches General and Environmental Physiology (9 C.F.U.) for the Degree Course in Environmental and Natural Sciences (1st level), Ecophysiological Adaptations to the Environment for the Degree Course in Environmental Biology, Physiology for the Degree Courses in Nursing, Radiology and Radiotherapy Technicians, and Environmental Safety Technicians, and Biophysics Physiology I Channel A and Channel C (8 C.F.U.) for the Degree Course in Medicine and Surgery (five-year).

She has held lessons for the second level University Masters "Monitoring and assessment of environmental, mutagenic, carcinogenic and teratogenic risk" and "Monitoring of ionizing and non-ionizing radiation and environmental risk", at the theoretical-practical training and professional development course organized in Catania by the National Order of Biologists, at the specialized training course "New figures of advanced technology specialists for the identification and analysis of biomarkers in the oncology sector" entrusted by the Company Medical Sciences s.r.l. within the Industrial Research and Training Project PON01_02418 and for the National Research Council (CNR) - Institute of Neurological Sciences UOS of Catania within the training project connected to the Project "DNA on Disk: Diagnostic platform and kits for human health in the oncology, neurological and infectious diseases and poverty-related diseases" - CTN01_00177_817708, financed by the resources of the program National Operational "Research & Competitiveness (PON "R&C") PON01_0248.

Research Interest: Environmental Physiology,Cell cultures; Cell models; Cell physiology; Signal transduction; Gene expression; Proteomics; Mesenchymal stem cell biology and differentiation ; Krabbe disease, e

Research Interest: Gene expression, gene therapy, cell biology, neurodegenerative disease, male and female infertility.

Research Interest: Diabetes and its Complications, Osteoporosis, Cardiovascular Disease, Neuropathy; Mathematical Modelling for Human Complex Disease; Policy and Clinical Decision Analysis in Medical Science; Stochastic Process Analysis and Bayesian Analysis for Clinical Medicine; Mathematical Methodology Development for Clinical Science; Gene Mapping and Identification of Human Complex Disease; Data Analysis for Results of Experiment